Modeling of 31P-NMR spectra of magnetically oriented phospholipid liposomes:: A new analytical solution

被引：25

作者：

Dubinnyi, MA ^{[1
]}

Lesovoy, DM ^{[1
]}

Dubovskii, PV ^{[1
]}

Chupin, VV ^{[1
]}

Arseniev, AS ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

SOLID STATE NUCLEAR MAGNETIC RESONANCE | 2006年 / 29卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

P-31-NMR spectroscopy; prolate phospholipid liposomes; deformation by the magnetic field; modeling of NMR spectra; analytical formula for spectrum lineshape; mathematica (Wolfram research);

D O I：

10.1016/j.ssnmr.2005.10.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

P-31-NMR spectroscopy is widely used for studies of phospholipid liposomes. a commonly used model of a biological membrane. For take into account that they are deformed by the magnetic field the correct analysis of P-31-NMR spectra of the liposomes it is necessary to take of the spectrometer. The liposomes become ellipsoidal and this affects the lineshape of the spectrum. In the present communication we suggest a new analytical formula for modeling of P-31-NMR spectra of the prolate phospholipid liposomes. The formula assumes a Lorentzian broadening function and exactly ellipsoidal shape of the liposomes. Based oil the formula a program called P-FIT is designed for the practical analysis of the experimental multicomponent spectra of the prolate liposomes. The versatility of the program developed in a Mathematica environment is demonstrated by simulations of a number of P-31-NMR spectra with different complexity. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：305 / 311

页数：7

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