Total Synthesis and Determination of the Absolute Configuration of Vinylamycin

被引：15
|
作者：
Yang, Zhantao [1 ,2 ]
Yang, Guang [1 ,2 ]
Ma, Meiyan [1 ,2 ]
Li, Jiangnan [3 ]
Liu, Jianwei [1 ,2 ]
Wang, Jinghan [1 ,2 ]
Jiang, Shende [3 ]
Zhang, Quan [1 ,2 ]
Chen, Yue [1 ,2 ]
机构：
[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China
[3] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 23期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
RAKICIDIN;
D O I：
10.1021/acs.orglett.5b02809
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
引用
收藏
页码：5725 / 5727
页数：3
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