Successful Treatment of Granulomatous Amoebic Encephalitis with Combination Antimicrobial Therapy

被引：13

作者：

Kato, Hideki ^{[1
]}

Mitake, Shigehisa ^{[1
]}

Yuasa, Hiroyuki ^{[1
]}

Hayashi, Shigemasa ^{[1
]}

Hara, Tatsuru ^{[1
]}

Matsukawa, Noriyuki ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Parasitol, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2013年 / 52卷 / 17期

关键词：

granulomatous amoebic encephalitis (GAE); antimicrobial therapy; free-living amoebae; cerebrospinal fluid (CSF); FREE-LIVING AMEBAS; BALAMUTHIA-MANDRILLARIS; NAEGLERIA-FOWLERI; MENINGOENCEPHALITIS; DIAGNOSIS; ANIMALS; HUMANS; GENE; DNA; PCR;

D O I：

10.2169/internalmedicine.52.0299

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Granulomatous amoebic encephalitis (GAE) is a rare but fatal infection. Due to its nonspecific symptoms and laboratory and neuroradiological findings, it is rarely diagnosed antemortem. We herein present the case of a 72-year-old Japanese woman who was diagnosed with GAE following the detection of a pathogen similar to Balamuthia mandrillaris under a microscopic examination of cerebrospinal fluid sediment and who achieved remission with combination antimicrobial therapy. There are no previous reports of pathogens similar to B. mandrillaris being detected in cerebrospinal fluid antemortem; therefore, this case may be used as a benchmark for further studies.

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页码：1977 / 1981

页数：5

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