Long Non-Coding RNA and Acute Leukemia

被引：50
|
作者：
Marisol Cruz-Miranda, Gabriela [1 ]
Hidalgo-Miranda, Alfredo [2 ]
Alberto Barcenas-Lopez, Diego [1 ]
Carlos Nunez-Enriquez, Juan [3 ]
Ramirez-Bello, Julian [4 ]
Manuel Mejia-Arangure, Juan [5 ]
Jimenez-Morales, Silvia [2 ]
机构：
[1] Univ Nacl Autonoma Mexico, Ciencias Biol, Programa Doctorado, Mexico City 04510, DF, Mexico
[2] Inst Nacl Med Genom, Lab Genom Canc, Mexico City 14610, DF, Mexico
[3] UMAE Hosp Pediat Dr Silvestre Frenk Freund, Unidad Invest Med Epidemiol Clin, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Mexico City 06720, DF, Mexico
[4] Hosp Juarez Mexico, Unidad Invest Enfermedades Metab & Endocrinas, Mexico City 07760, DF, Mexico
[5] Inst Mexicano Seguro Social, Coordinac Invest Salud, Mexico City 06720, DF, Mexico
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 03期
关键词：
long non-coding RNAs; cancer; acute leukemia; therapeutic targets; ACUTE LYMPHOBLASTIC-LEUKEMIA; PROMOTES CELL-PROLIFERATION; ACUTE MYELOID-LEUKEMIA; PROGNOSTIC BIOMARKER; UNIQUE FEATURES; EXPRESSION; GENE; APOPTOSIS; HOTAIRM1; CANCER;
D O I：
10.3390/ijms20030735
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.
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页数：17
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