Plasmacytoid Dendritic Cells in HIV Infection

被引：59

作者：

O'Brien, Meagan ^{[1
]}

Manches, Olivier ^{[2
]}

Bhardwaj, Nina ^{[3
]}

机构：

[1] NYU, Sch Med, Inst Canc, Div Infect Dis,Dept Med, New York, NY 10016 USA

[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

[3] NYU, Sch Med, Inst Canc, Dept Med Dermatol & Pathol, New York, NY 10016 USA

来源：

HIV INTERACTIONS WITH DENDRITIC CELLS: INFECTION AND IMMUNITY | 2013年 / 762卷

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; REGULATORY T-CELLS; ALPHA-INTERFERON PRODUCTION; PATHOGENIC SIV INFECTION; INNATE IMMUNE-SYSTEM; INFLAMED LYMPH-NODES; I INTERFERON; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; RHESUS MACAQUES;

D O I：

10.1007/978-1-4614-4433-6_3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are innate immune cells that are specialized to produce interferon-alpha (IFN alpha) and participate in activating adaptive immune responses. Although IFN alpha inhibits HIV-1 (HIV) replication in vitro, pDCs may act as inflammatory and immunosuppressive dendritic cells (DCs) rather than classical antigen-presenting cells during chronic HIV infection in vivo, contributing more to HIV pathogenesis than to protection. Improved understanding of HIV-pDC interactions may yield potential new avenues of discovery to prevent HIV transmission, to blunt chronic immune activation and exhaustion, and to enhance beneficial adaptive immune responses. In this chapter we discuss pDC biology, including pDC development from progenitors, trafficking and localization of pDCs in the body, and signaling pathways involved in pDC activation. We focus on the role of pDCs in HIV transmission, chronic disease progression and immune activation, and immunosuppression through regulatory T cell development. Lastly, we discuss potential future directions for the field which are needed to strengthen our current understanding of the role of pDCs in HIV transmission and pathogenesis.

引用

页码：71 / 107

页数：37

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