Targeting the 'Janus face' of the B2-bradykinin receptor

被引:46
作者
Blaes, Nelly [1 ]
Girolami, Jean-Pierre [1 ]
机构
[1] Univ Toulouse 3, INSERM, Inst Metab & Cardiovasc Dis, U1048,I2MC, F-31432 Toulouse, France
关键词
agonism; angiotensin; angiotensin-converting enzyme; antagonism; B2-kinin receptor; bradykinin; cardiovascular; diabetes; hypertension; inflammation; KALLIKREIN-KININ SYSTEM; BRADYKININ B-2 RECEPTOR; CONVERTING ENZYME-INHIBITION; DUCHENNE MUSCULAR-DYSTROPHY; ARACHIDONIC-ACID RELEASE; B2; RECEPTOR; ANGIOTENSIN-II; TISSUE KALLIKREIN; HEREDITARY ANGIOEDEMA; MEDIATED INFLAMMATION;
D O I
10.1517/14728222.2013.827664
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Kinins are main active mediators of the kallikrein-kinin system (KKS) via bradykinin type 1 inducible (B1R) and type 2 constitutive (B2R) receptors. B2R mediates most physiological bradykinin (BK) responses, including vasodilation, natriuresis, NO, prostaglandins release. Areas covered: The article summarizes knowledge on kinins, B2R signaling and biological functions; highlights crosstalks between B2R and renin-angiotensin system (RAS). The double role (Janus face) in physiopathology, namely the beneficial protection of the endothelium, which forms the basis for the therapeutical utilization of B2 receptor agonists, on the one side, and the involvement of B2R in inflammation or infection diseases and in pain mechanisms, which justifies the use of B2R antagonists, on the other side, is extensively analyzed. Expert opinion: For decades, the B2R has been unconsciously activated during angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) treatments. Whether direct B2R targeting with stable agonists could bring additional therapeutic benefit to RAS inhibition should be investigated. Efficacy, established in experimental models, should be confirmed by translational studies in cardiovascular pathologies, glaucoma, Duchenne cardiopathy and during brain cancer therapy. The other face of B2R is targeted by antagonists already approved to treat hereditary angioedema. The use of antagonists could be extended to other angioedema and efficacy tested against acute pain and inflammatory diseases.
引用
收藏
页码:1145 / 1166
页数:22
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