Effects of adrenodemedullation and adrenalectomy on the 5-HT2 receptor agonists DOI- and mCPP-induced hypophagia in rats

Effects of adrenomedullation and adrenalectomy on the serotonin(2) (5-HT2) receptor agonists-induced hypophagia were investigated. Hypophagia induced by both the 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the 5-HT2C receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) were not affected by adrenodemedullation. In adrenolectomized rats, DOI did not induce hypophagia, while mCPP elicited apparent effects. These results suggest that neither DOI- nor mCPP-induced hypophagia was not associated with adrenaline release from the adrenal medulla. Moreover, our results suggest that DOI-induced hypophagia is involved in corticosterone-sensitive feeding, although other mechanisms which are not related to corticosterone are involved in mCPP-induced anorexia.