Haloperidol increases spreading and nitric oxide production in macrophages from tumor-bearing mice: a possible mechanism for its antitumoral effect

被引:22
作者
Kleeb, SR
Rizzo, MD
Dagli, MLZ
Frussa, R
机构
[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo, Brazil
来源
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1999年 / 21卷 / 09期
基金
巴西圣保罗研究基金会;
关键词
haloperidol; Ehrlich adenocarcinoma; macrophage; nitric oxide;
D O I
10.1016/S0192-0561(99)00036-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase both the percent of macrophage spreading and nitric oxide (NO) release in peritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10(6) Ehrlich ascites cells. This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma. (C) 1999 International Society for Immunopharmacology, Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:575 / 580
页数:6
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