Nanoparticles as vehicles for delivery of photodynamic therapy agents

被引：648

作者：

Bechet, Denise ^{[1
]}

Couleaud, Pierre ^{[2
]}

Frochot, Celine ^{[2
]}

Viriot, Marie-Laure ^{[2
]}

Guillemin, Francois ^{[1
]}

Barberi-Heyob, Muriel ^{[1
]}

机构：

[1] Nancy Univ, Ctr Alexis Vautrin, CNRS, Ctr Rech Automat Nancy, F-54511 Vandoeuvre Les Nancy, France

[2] Nancy Univ, CNRS, Dept Chim Phys React, DCPR, F-54001 Nancy, France

来源：

TRENDS IN BIOTECHNOLOGY | 2008年 / 26卷 / 11期

关键词：

D O I：

10.1016/j.tibtech.2008.07.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Photodynamic therapy (PDT) in cancer treatment involves the uptake of a photosensitizer by cancer tissue followed by photoirradiation. The use of nanoparticles as carriers of photosensitizers is a very promising approach because these nanomaterials can satisfy all the requirements for an ideal PDT agent. This review describes and compares the different individual types of nanoparticles that are currently in use for PDT applications. Recent advances in the use of nanoparticles, including inorganic oxide-, metallic-, ceramic-, and biodegradable polymer-based nanomaterials as carriers of photosensitizing agents, are highlighted. We describe the nanoparticles in terms of stability, photocytotoxic efficiency, biodistribution and therapeutic efficiency. Finally, we summarize exciting new results concerning the improvement of the photophysical properties of nanoparticles by means of biphotonic absorption and upconversion.

引用

页码：612 / 621

页数：10

共 72 条

[1] PEG-COATED POLY(LACTIC ACID) NANOPARTICLES FOR THE DELIVERY OF HEXADECAFLUORO ZINC PHTHALOCYANINE TO EMT-6 MOUSE MAMMARY-TUMORS [J].

ALLEMANN, E ;

BRASSEUR, N ;

BENREZZAK, O ;

ROUSSEAU, J ;

KUDREVICH, SV ;

BOYLE, RW ;

LEROUX, JC ;

GURNY, R ;

VANLIER, JE .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1995, 47 (05) :382-387

[2]

Allemann E, 1996, INT J CANCER, V66, P821, DOI 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO

[3]

2-5

[4] Bio-nanotechnology and photodynamic therapy - State of the art review [J].

Allison, R. R. ;

Mota, H. C. ;

Bagnato, V. S. ;

Sibata, C. H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2008, 5 (01) :19-28

[5] Biodegradation and biocompatibility of PLA and PLGA microspheres [J].

Anderson, JM ;

Shive, MS .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) :5-24

[6] PDT: light at the end of the tunnel? [J].

Brown, M .

DRUG DISCOVERY TODAY, 2003, 8 (17) :767-768

[7] Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment [J].

Chen, W ;

Zhang, J .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2006, 6 (04) :1159-1166

[8]

Chen W, 2007, NANOPARTICLE BASED P

[9] Sensibilization of fullerene C60 immobilized at silica nanoparticles for cancer photodynamic therapy [J].

Davydenko, M. O. ;

Radchenko, E. O. ;

Yashchuk, V. M. ;

Dmitruk, I. M. ;

Prylutskyy, Yu. I. ;

Matishevska, O. P. ;

Golub, A. A. .

JOURNAL OF MOLECULAR LIQUIDS, 2006, 127 (1-3) :145-147

[10] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

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