A case of pyoderma gangrenosum with ulcerative colitis treated with combined approach: Infliximab and surgery

被引：15
作者：
Andrisani, G. [1 ]
Guidi, L. [1 ]
Papa, A. [1 ]
Potenza, A. E. [2 ]
Cervelli, D. [2 ]
Armuzzi, A. [1 ]
机构：
[1] Catholic Univ, Internal Med & Gastroenterol Unit, Rome, Italy
[2] Catholic Univ, Dept Surg, Rome, Italy
来源：
JOURNAL OF CROHNS & COLITIS | 2013年 / 7卷 / 05期
关键词：
Infliximab; Pyoderma gangrenosum; Ulcerative colitis; Surgery; ADALIMUMAB TREATMENT; CYCLOSPORINE; MANAGEMENT; PATIENT;
D O I：
10.1016/j.crohns.2012.07.021
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pyoderma gangrenosum (PG) is an ulcerating noninfectious disease of the skin seen in 1-2% of patients with inflammatory bowel disease (IBD). The pathogenesis of PG has yet to be determined, but may be related to abnormal T cell responses and the production of TNF-alpha, a pathway also involved in IBD pathogenesis. Infliximab, a chimeric monoclonal antibody to TNF-alpha, is used to treat moderate to severe IBD and several case reports and studies suggest the efficacy of infliximab in the treatment of PG. The surgical approach to PG is reserved to a few selected cases. We report here the case of a patient with ulcerative colitis (UC) and PG localized on the left breast, treated with a simultaneous combined medical and surgical approach. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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收藏
页码：421 / 426
页数：6
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