Synthesis, Cytotoxicity, and Apoptosis Induction Study of Antitumor Dinuclear Platinum(II) Complexes

被引：7
|
作者：
Xu, Gang [1 ,2 ]
Gou, Shaohua [1 ,2 ]
Gao, Chuanzhu [2 ,3 ]
机构：
[1] Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Chem & Chem Engn, Pharmaceut Res Ctr, Nanjing 211189, Jiangsu, Peoples R China
[3] Kunming Univ Sci & Technol, Sch Life Sci & Technol, Kunming, Peoples R China
来源：
ARCHIV DER PHARMAZIE | 2013年 / 346卷 / 04期
基金：
中国国家自然科学基金;
关键词：
3-(2-Amino-cyclohexylamino)-propionic acid; Apoptosis induction; Cytotoxicity; Dinuclear platinum complex; IN-VITRO; DNA;
D O I：
10.1002/ardp.201200288
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3-(2-amino-cyclohexylamino)-propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG-2, MCF-7, A549, and HCT-116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG-2 cell line. Particularly, complex X5, which has SO42 as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis.
引用
收藏
页码：308 / 313
页数：6
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