Effect of monopolar radiofrequency treatment over soft-tissue fillers in an animal model: Part 2

被引:29
作者
Shumaker, PR
England, LJ
Dover, JS
Ross, EV
Harford, R
DeRienzo, D
Bogle, M
Uebelhoer, N
Jacoby, M
Pope, K
机构
[1] Thermage Inc, Hayward, CA USA
[2] USN, Med Ctr, San Diego, CA 92152 USA
[3] SkinCare Phys, Chestnut Hill, MA USA
关键词
collagen; laxity; non-ablative; RF; skin tightening; Thermacool; Thermage;
D O I
10.1002/lsm.20292
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Objectives: Monopolar radiofrequency (RF) treatment is used by physicians to heat skin and promote tissue tightening and contouring. Cosmetic fillers are used to soften deep facial lines and wrinkles. Patients who have had dermal fillers implanted may also benefit from or are candidates for monopolar RF skin tightening. This study examined the effect of RF treatment on various dermal filler substances. This is the second part of a two-part study. Study Design/Materials and Methods: Ajuvenile farm pig was injected with dermal fillers including cross-linked human collagen (Cosmoplast (TM)), polylactic acid (PLA) (Sculptra (TM)), liquid injectable silicone (Silikon (TM) 1000), calcium hydroxylapatite (CaHA) (Radiesse (TM)), and hyaluronic acid (Restylane (R)). Skin injected with dermal fillers was RF-treated using a 1.5-cm(2) treatment tip and treatment levels typically used in the clinical setting. Fillers were examined histologically 5 days, 2 weeks, or 1 month after treatment. Histological specimens were scored for inflammatory response, foreign body response, and fibrosis in order to assess the effect of treatment on early filler processes, such as inflammation and encapsulation. Results: Each filler substance produced a characteristic inflammatory response. No immediate thermal effect of RF treatment was observed histologically. RF treatment resulted in statistically significant increases in the inflammatory, foreign body, and fibrotic responses associated with the filler substances. Conclusions: Monopolar RF treatment levels that are typically used in the clinical setting were employed in this animal study. RF treatment resulted in measurable and statistically significant histological changes associated with the various filler materials. Additional clinical and histological studies are required to determine the optimal timing of monopolar RF treatment and filler placement for maximal potential aesthetic outcome.
引用
收藏
页码:211 / 217
页数:7
相关论文
共 30 条
[1]   Nonablative laser and light treatments:: Histology and tissue effects -: A review [J].
Alam, M ;
Hsu, TS ;
Dover, JS ;
Wrone, DA ;
Arndt, KA .
LASERS IN SURGERY AND MEDICINE, 2003, 33 (01) :30-39
[2]  
[Anonymous], 1988, J DERMATOL SURG ONCO
[3]   Injecting 1000 centistoke liquid silicone with ease and precision [J].
Benedetto, AV ;
Lewis, AT .
DERMATOLOGIC SURGERY, 2003, 29 (03) :211-214
[4]   A FOREIGN-BODY GRANULOMA PRODUCED BY AN INJECTABLE COLLAGEN IMPLANT AT A TEST SITE [J].
BROOKS, N .
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1982, 8 (02) :111-114
[5]   BOVINE COLLAGEN IMPLANT - HISTOLOGIC CHRONOLOGY IN PIG DERMIS [J].
BURKE, KE ;
NAUGHTON, G ;
WALDO, E ;
CASSAI, N .
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1983, 9 (11) :889-895
[6]   DERMAL IMPLANTS - SAFETY OF PRODUCTS INJECTED FOR SOFT-TISSUE AUGMENTATION [J].
CLARK, DP ;
HANKE, CW ;
SWANSON, NA .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 21 (05) :992-998
[7]   The silicone conundrum: A battle of anecdotes [J].
Duffy, DM .
DERMATOLOGIC SURGERY, 2002, 28 (07) :590-594
[8]   Injectable hyaluronic acid gel for soft tissue augmentation - A clinical and histological study [J].
Duranti, F ;
Salti, G ;
Bovani, B ;
Calandra, M ;
Rosati, ML .
DERMATOLOGIC SURGERY, 1998, 24 (12) :1317-1325
[9]   Effects of monopolar radiofrequency treatment over soft-tissue fillers in an animal model [J].
England, LJ ;
Tan, MH ;
Shumaker, PR ;
Egbert, BM ;
Pittelko, K ;
Orentreich, D ;
Pope, K .
LASERS IN SURGERY AND MEDICINE, 2005, 37 (05) :356-365
[10]  
ENGLAND LJ, UNPUB DERMAL WOUND H