Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

被引：117
作者：
Merendino, Nicolo [1 ]
Costantini, Lara [1 ]
Manzi, Laura [1 ]
Molinari, Romina [1 ]
D'Eliseo, Donatella [1 ]
Velotti, Francesca [1 ]
机构：
[1] Univ Tuscia, Dept Ecol & Biol Sci DEB, Largo Univ, I-01100 Viterbo, Italy
来源：
BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷
关键词：
TRIOXIDE-MEDIATED APOPTOSIS; DOCOSAHEXAENOIC ACID; BREAST-CANCER; FISH-OIL; GRANZYME-B; HYDROGEN-PEROXIDE; BASEMENT-MEMBRANE; COLON-CARCINOMA; DOWN-REGULATION; TUMOR-GROWTH;
D O I：
10.1155/2013/310186
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
omega-3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.
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页数：11
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