Development of γδ T cells in the thymus - A human perspective

被引：18

作者：

Boehme, Lena ^{[1
]}

Roels, Juliette ^{[1
]}

Taghon, Tom ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Diagnost Sci, Ghent, Belgium

[2] Canc Res Inst Ghent CRIG, Ghent, Belgium

来源：

SEMINARS IN IMMUNOLOGY | 2022年 / 61卷

关键词：

gamma delta T cells; T cell development; Lineage commitment; Human; Thymocyte; Thymus; LOOP-HELIX PROTEINS; TCR-ALPHA-BETA; VARIABLE REGION GENES; V-J RECOMBINATION; RECEPTOR-GAMMA; INTERLEUKIN-7; RECEPTOR; C-MYB; THYMOCYTE DEVELOPMENT; LINEAGE COMMITMENT; NATURAL-KILLER;

D O I：

10.1016/j.smim.2022.101662

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

gamma delta T cells are increasingly emerging as crucial immune regulators that can take on innate and adaptive roles in the defence against pathogens. Although they arise within the thymus from the same hematopoietic precursors as conventional alpha beta T cells, the development of gamma delta T cells is less well understood. In this review, we focus on summarising the current state of knowledge about the cellular and molecular processes involved in the gener-ation of gamma delta T cells in human.

引用

收藏

页数：15

相关论文

共 218 条

[1] Human gamma delta T cells: Evolution and ligand recognition [J].

Adams, Erin J. ;

Gu, Siyi ;

Luoma, Adrienne M. .

CELLULAR IMMUNOLOGY, 2015, 296 (01) :31-40

[2] αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals [J].

Aghaallaei, Narges ;

Dick, Advaita M. ;

Tsingos, Erika ;

Inoue, Daigo ;

Hasel, Eva ;

Thumberger, Thomas ;

Toyoda, Atsushi ;

Leptin, Maria ;

Wittbrodt, Joachim ;

Bajoghli, Baubak .

SCIENCE ADVANCES, 2021, 7 (29)

[3] Induction of T helper type 2 immunity by a point mutation in the LAT adaptor [J].

Aguado, E ;

Richelme, S ;

Nuñez-Cruz, S ;

Miazek, A ;

Mura, AM ;

Richelme, M ;

Guo, XJ ;

Sainty, D ;

He, HT ;

Malissen, B ;

Malissen, M .

SCIENCE, 2002, 296 (5575) :2036-2040

[4] A critical role for the cytoplasmic tail of pTα in T lymphocyte development [J].

Aifantis, I ;

Borowski, C ;

Gounari, F ;

Lacorazza, HD ;

Nikolich-Zugich, J ;

von Boehmer, H .

NATURE IMMUNOLOGY, 2002, 3 (05) :483-488

[5] INTERLEUKIN-7-INDUCED EXPRESSION OF SPECIFIC T-CELL RECEPTOR-GAMMA VARIABLE REGION GENES IN MURINE FETAL LIVER CULTURES [J].

APPASAMY, PM ;

KENNISTON, TW ;

WENG, YH ;

HOLT, EC ;

KOST, J ;

CHAMBERS, WH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2201-2206

[6] Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment [J].

Asnafi, V ;

Beldjord, K ;

Boulanger, E ;

Comba, B ;

Le Tutour, P ;

Estienne, MH ;

Davi, F ;

Landman-Parker, J ;

Quartier, P ;

Buzyn, A ;

Delabesse, E ;

Valensi, F ;

Macintyre, E .

BLOOD, 2003, 101 (07) :2693-2703

[7] Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade [J].

Bain, G ;

Cravatt, CB ;

Loomans, C ;

Alberola-Ila, J ;

Hedrick, SM ;

Murre, C .

NATURE IMMUNOLOGY, 2001, 2 (02) :165-171

[8] Positive and negative regulation of V(D)J recombination by the E2A proteins [J].

Bain, G ;

Romanow, WJ ;

Albers, K ;

Havran, WL ;

Murre, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :289-300

[9] Skint-1 is a highly specific, unique selecting component for epidermal T cells [J].

Barbee, Susannah D. ;

Woodward, Martin J. ;

Turchinovich, Gleb ;

Mention, Jean-Jacques ;

Lewis, Julia M. ;

Boyden, Lynn M. ;

Lifton, Richard P. ;

Tigelaar, Robert ;

Hayday, Adrian C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (08) :3330-3335

[10]

Blom B, 1999, BLOOD, V93, P3033

← 1 2 3 4 5 6 7 8 9 10 →