Daptomycin for the treatment of gram-positive infections after cardiac surgery

被引：0
|
作者：
Luchting, B. [1 ]
Weis, F. [1 ]
Heyn, J. [1 ]
Beiras-Fernandez, A. [2 ,3 ]
机构：
[1] Klinikum Univ Munchen, Klin Anaesthesiol, Munich, Germany
[2] Klinikum Univ Munchen, Herzchirurg Klin & Poliklin, Munich, Germany
[3] Klinikum Johann Wolfgang Goethe Univ, D-60590 Frankfurt, Germany
来源：
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN | 2013年 / 108卷 / 01期
关键词：
Gram-positive Infections; Daptomycin; Cardiac surgery; Resistences; Efficacy; RESISTANT STAPHYLOCOCCUS-AUREUS; MAJOR HEART-SURGERY; POSTOPERATIVE MEDIASTINITIS; CLINICAL-EVIDENCE; JOINT INFECTIONS; VANCOMYCIN; THERAPY; ENDOCARDITIS; BACTEREMIA; PATIENT;
D O I：
10.1007/s00063-012-0163-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and method. Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. Conclusion. Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus.
引用
收藏
页码：59 / 62
页数：4
相关论文
共 50 条
  • [21] Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections
    Steenbergen, JN
    Alder, J
    Thorne, GM
    Tally, FP
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (03) : 283 - 288
  • [22] Daptomycin: a rapidly bactericidal lipopeptide for the treatment of Gram-positive infections
    Konafani, Zeina A.
    Corey, G. Ralph
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2007, 5 (02) : 177 - 184
  • [23] Optimizing outcomes in patients with serious Gram-positive infections
    Miro, J. M.
    CLINICAL MICROBIOLOGY AND INFECTION, 2009, 15 : 1 - 4
  • [24] Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections
    Di Paolo, Antonello
    Tascini, Carlo
    Polillo, Marialuisa
    Gemignani, Giulia
    Nielsen, Elisabet I.
    Bocci, Guido
    Karlsson, Mats O.
    Menichetti, Francesco
    Danesi, Romano
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2013, 42 (03) : 250 - 255
  • [25] Daptomycin use in neutropenic patients with documented gram-positive infections
    Rolston, Kenneth V. I.
    Besece, Dina
    Lamp, Kenneth C.
    Yoon, Min
    McConnell, Scott A.
    White, Pamela
    SUPPORTIVE CARE IN CANCER, 2014, 22 (01) : 7 - 14
  • [26] Daptomycin: pharmacological characteristics and its role in the treatment of gram positive infections
    Araos, Rafael
    Garcia, Patricia
    Chanqueo, Leonardo
    Labarca, Jaime
    REVISTA CHILENA DE INFECTOLOGIA, 2012, 29 (02): : 127 - 131
  • [27] Daptomycin: a new treatment for insidious infections due to gram-positive pathogens
    Cottagnoud, Philippe
    SWISS MEDICAL WEEKLY, 2008, 138 (7-8) : 93 - 99
  • [28] Factors associated with development of nephrotoxicity in patients treated with vancomycin versus daptomycin for severe Gram-positive infections: A practice-based study
    Barberan, Jose
    Mensa, Jose
    Artero, Arturo
    Epelde, Francisco
    Rodriguez, Juan-Carlos
    Ruiz-Morales, Josefa
    Calleja, Jose-Luis
    Guerra, Jose-Manuel
    Martinez-Gil, Inigo
    Gimenez, Maria-Jose
    Granizo, Juan-Jose
    Aguilar, Lorenzo
    REVISTA ESPANOLA DE QUIMIOTERAPIA, 2019, 32 (01) : 22 - 30
  • [29] Daptomycin Population Pharmacokinetics in Patients Affected by Severe Gram-Positive Infections: An Update
    Balice, Giuseppe
    Passino, Claudio
    Bongiorni, Maria Grazia
    Segreti, Luca
    Russo, Alessandro
    Lastella, Marianna
    Luci, Giacomo
    Falcone, Marco
    Di Paolo, Antonello
    ANTIBIOTICS-BASEL, 2022, 11 (07):
  • [30] Safety and Efficacy of Daptomycin in the Treatment of Gram-Positive Pathogens
    Kelesidis, Theodoros
    CLINICAL MEDICINE INSIGHTS-THERAPEUTICS, 2011, 3 : 403 - 414
12345