Daptomycin for the treatment of gram-positive infections after cardiac surgery

被引：0
|
作者：
Luchting, B. [1 ]
Weis, F. [1 ]
Heyn, J. [1 ]
Beiras-Fernandez, A. [2 ,3 ]
机构：
[1] Klinikum Univ Munchen, Klin Anaesthesiol, Munich, Germany
[2] Klinikum Univ Munchen, Herzchirurg Klin & Poliklin, Munich, Germany
[3] Klinikum Johann Wolfgang Goethe Univ, D-60590 Frankfurt, Germany
来源：
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN | 2013年 / 108卷 / 01期
关键词：
Gram-positive Infections; Daptomycin; Cardiac surgery; Resistences; Efficacy; RESISTANT STAPHYLOCOCCUS-AUREUS; MAJOR HEART-SURGERY; POSTOPERATIVE MEDIASTINITIS; CLINICAL-EVIDENCE; JOINT INFECTIONS; VANCOMYCIN; THERAPY; ENDOCARDITIS; BACTEREMIA; PATIENT;
D O I：
10.1007/s00063-012-0163-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and method. Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. Conclusion. Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus.
引用
收藏
页码：59 / 62
页数：4
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