The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats

被引：90

作者：

Karadeniz, Ali ^{[1
]}

Cemek, Mustafa ^{[2
]}

Simsek, Nejdet ^{[3
]}

机构：

[1] Ataturk Univ, Dept Physiol, Fac Vet, TR-25700 Erzurum, Turkey

[2] Afyon Kocatepe Univ, Dept Chem, Fac Art & Sci, TR-03100 Afyon, Turkey

[3] Ataturk Univ, Dept Histol & Embryol, Fac Vet, TR-25700 Erzurum, Turkey

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2009年 / 72卷 / 01期

关键词：

Spirulina platensis; Panax ginseng; Cadmium; Hepatic damage; Rat; ANTIOXIDANT DEFENSE SYSTEM; INDUCED LIPID-PEROXIDATION; SUPEROXIDE-DISMUTASE; VITAMIN-E; LIVER; ERYTHROCYTES; GLUTATHIONE; CATALASE; TISSUES; PLASMA;

D O I：

10.1016/j.ecoenv.2008.02.021

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Cadmium is an environmental and industrial cumulative pollutant that affects many organs, specially the liver. The protective effect of Spirulina platensis and Panax ginseng on cadmium-induced oxidative stress and hepatotoxicity was evaluated in adult female Wistar albino rats. At the end of the 1-month experimental period, all animals were fasted for 12 h and liver samples were taken for the determination of malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels. S. platensis and P. ginseng treatments showed marked decrease lipid peroxidation and increase of the endogenous antioxidants levels. The cadmium-induced histopathological changes were also minimized with the tested extracts. These results suggest that S. platensis and P. ginseng might play a role in reducing the toxic effect of cadmium and its antioxidant properties seem to mediate such a protective effect. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：231 / 235

页数：5

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