mTOR, linking metabolism and immunity

被引：76
作者：
Xu, Xiaojin
Ye, Lilin
Araki, Koichi
Ahmed, Rafi
机构：
[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
来源：
SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 06期
关键词：
mTOR; Rapamycin; T cells; B cells; Metabolism; Autophagy; T-CELL DIFFERENTIATION; MAMMALIAN TARGET; REGULATES EFFECTOR; CYCLE PROGRESSION; RAPAMYCIN; ACTIVATION; AUTOPHAGY; MEMORY; RECEPTOR; PATHWAY;
D O I：
10.1016/j.smim.2012.12.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse signals from the immune microenvironment and coordinating the functions of immune cells and their metabolism. In CD8 T cells, mTOR has shown to influence cellular commitment to effector versus memory programming; in CD4 T cells, mTOR integrates environmental cues that instruct effector cell differentiation. In this review, we summarize and discuss recent advances in the field, with a focus on the mechanisms through which mTOR regulates cellular and humoral immunity. Further understanding will enable the manipulation of mTOR signaling to direct the biological functions of immune cells, which holds great potential for improving immune therapies and vaccination against infections and cancer. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：429 / 435
页数：7
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