Pd(II)-Catalyzed Asymmetric Oxidative Annulation of N-Alkoxyheteroaryl Amides and 1,3-Dienes

被引：43
|
作者：
Zhang, Tao [1 ,2 ,3 ]
Shen, Hong-Cheng [1 ,2 ,3 ]
Xu, Jia-Cheng [1 ,2 ]
Fan, Tao [1 ,2 ]
Han, Zhi-Yong [1 ,2 ]
Gong, Liu-Zhu [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 07期
关键词：
C-H ACTIVATION; CONJUGATED DIENES; ALKENES; FUNCTIONALIZATION; LIGANDS; 1,2-DIFUNCTIONALIZATION; DIFUNCTIONALIZATION; PALLADIUM(II); INDOLES; OLEFINS;
D O I：
10.1021/acs.orglett.9b00216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first Pd(II)-catalyzed asymmetric oxidative annulation of N-alkoxyaryl amides and 1,3-dienes is reported, which features particular applicability for quick assembly of different types of chiral heterocycles with high yields and enantioselectivities. A novel chiral pyridine-oxazoline bearing a methoxyl group at the C-5 position and a gem-dimethyl group on the oxazoline moiety was found to be crucial for conversion.
引用
收藏
页码：2048 / 2051
页数：4
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