Tropomyosin and the Steric Mechanism of Muscle Regulation

被引：0

作者：

Lehman, William ^{[1
]}

Craig, Roger ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Physiol & Biophys, Boston, MA 02118 USA

来源：

TROPOMYOSIN | 2008年 / 644卷

关键词：

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Contraction in all muscles must be precisely regulated and requisite control systems must be able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline the structural evidence for a steric mechanism that governs muscle activity. the mechanism involves calcium and myosin induced changes in the position of tropomyosin along actin-based thin filaments. This process either blocks or uncovers myosin crossbridge binding sites on actin and consequently regulates crossbridge cycling on thin filaments, the sliding of thin and thick filaments and muscle shortening and force production.

引用

页码：95 / 109

页数：15

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