Interaction between polymeric multilayer capsules and immune cells

被引：21
作者：
Dierendonck, Marijke [1 ]
De Koker, Stefaan [1 ,2 ]
Vervaet, Chris [1 ]
Remon, Jean Paul [1 ]
De Geest, Bruno G. [1 ,2 ]
机构：
[1] Univ Ghent, Dept Pharmaceut, Lab Pharmaceut Technol, B-9000 Ghent, Belgium
[2] Univ Ghent, Dept Biomed Mol Biol, Lab Mol Immunol, B-9000 Ghent, Belgium
来源：
JOURNAL OF CONTROLLED RELEASE | 2012年 / 161卷 / 02期
关键词：
Polyelectrolytes; Capsules; Vaccines; Antigens; Immune cells; LAYER-BY-LAYER; IN-VIVO; POLYELECTROLYTE MICROCAPSULES; DRUG-DELIVERY; COLLOIDAL PARTICLES; DENDRITIC CELLS; CARGO RELEASE; FILMS; NANOPARTICLES; DEGRADATION;
D O I：
10.1016/j.jconrel.2012.03.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polymeric multilayer capsules are emerging carrier systems in the field of drug delivery. These materials are fabricated by set-wise assembly of interaction species onto a sacrificial template followed by the decomposition of this template, yielding hollow capsules. Using bio-responsive polymers that can be triggered by pH, enzymes or reduction, several groups are exploring these systems for intracellular drug delivery. In this review we focus on the recent efforts made in investigating the in vitro and in vivo interaction between these capsules and cells of the immune system. (c) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：592 / 599
页数：8
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