Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma

被引：42

作者：

Barroso, Elisa M. ^{[1
]}

ten Hove, Ivo ^{[1
]}

Schut, Tom C. Bakker ^{[2
]}

Mast, Hetty ^{[1
]}

van Lanschot, Cornelia G. F. ^{[3
]}

Smits, Roeland W. H. ^{[3
]}

Caspers, Peter J. ^{[2
]}

Verdijk, Rob ^{[4
]}

Hegt, Vincent Noordhoek ^{[4
]}

de Jong, Robert J. Baatenburg ^{[3
]}

Wolvius, Eppo B. ^{[1
]}

Puppels, Gerwin J. ^{[2
]}

Koljenovic, Senada ^{[4
]}

机构：

[1] Erasmus MC, Dept Oral & Maxillofacial Surg, POB 2040, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Dermatol, Ctr Opt Diagnost & Therapy, POB 2040, NL-3000 CA Rotterdam, Netherlands

[3] Erasmus MC, Dept Otorhinolaryngol & Head & Neck Surg, POB 2040, NL-3000 CA Rotterdam, Netherlands

[4] Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2018年 / 92卷

关键词：

Oral cancer surgery; Adequate resection margins; Intra-operative assessment; Mandible; Surgical oncology; INTRAOPERATIVE CYTOLOGICAL ASSESSMENT; FROZEN-SECTION; WATER CONCENTRATION; SURGICAL MARGIN; LOCAL-CONTROL; NECK-CANCER; FREE-FLAP; RECONSTRUCTION; HEAD; TISSUE;

D O I：

10.1016/j.ejca.2018.01.068

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: The aim of this study was to investigate the potential of Raman spectroscopy for detection of oral cavity squamous cell carcinoma (OCSCC) in bone resection surfaces during mandibulectomy. Materials & methods: Raman mapping experiments were performed on fresh mandible resection specimens from patients treated with mandibulectomy for OCSCC. A tumour detection algorithm was created based on water concentration and the high-wavenumber range (2800 cm(-1)-3050 cm(-1)) of the Raman spectra. Results: Twenty-six ex vivo Raman mapping experiments were performed on 26 fresh mandible resection specimens obtained from 22 patients. The algorithm was applied on an independent test set and showed an accuracy of 95%, a sensitivity of 95%, and a specificity of 87%. Conclusion: These results form the basis for further development of a Raman spectroscopy tool as an objective method for intraoperative assessment of bone resection margins. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：77 / 87

页数：11

共 48 条

[1] Early stage carcinoma of oral tongue: prognostic factors for local control and survival [J].

Al-Rajhi, N ;

Khafaga, Y ;

El-Husseiny, J ;

Saleem, M ;

Mourad, W ;

Al-Otieschan, A ;

Al-Amro, A .

ORAL ONCOLOGY, 2000, 36 (06) :508-514

[2] Application of Raman Spectroscopy to Identify Microcalcifications and Underlying Breast Lesions at Stereotactic Core Needle Biopsy [J].

Barman, Ishan ;

Dingari, Narahara Chari ;

Saha, Anushree ;

McGee, Sasha ;

Galindo, Luis H. ;

Liu, Wendy ;

Plecha, Donna ;

Klein, Nina ;

Dasari, Ramachandra Rao ;

Fitzmaurice, Maryann .

CANCER RESEARCH, 2013, 73 (11) :3206-3215

[3] Discrimination between Oral Cancer and Healthy Tissue Based on Water Content Determined by Raman Spectroscopy [J].

Barroso, E. M. ;

Smits, R. W. H. ;

Schut, T. C. Bakker ;

ten Hove, I. ;

Hardillo, J. A. ;

Wolvius, E. B. ;

de Jong, R. J. Baatenburg ;

Koljenovic, S. ;

Puppels, G. J. .

ANALYTICAL CHEMISTRY, 2015, 87 (04) :2419-2426

[4] Water Concentration Analysis by Raman Spectroscopy to Determine the Location of the Tumor Border in Oral Cancer Surgery [J].

Barroso, Elisa M. ;

Smits, Roeland W. H. ;

van Lanschot, Cornelia G. F. ;

Caspers, Peter J. ;

ten Hove, Ivo ;

Mast, Hetty ;

Sewnaik, Aniel ;

Hardillo, Jose A. ;

Meeuwis, Cees A. ;

Verdijk, Rob ;

Hegt, Vincent Noordhoek ;

de Jong, Robert J. Baatenburg ;

Wolvius, Eppo B. ;

Schut, Tom C. Bakker ;

Koljenovic, Senada ;

Puppels, Gerwin J. .

CANCER RESEARCH, 2016, 76 (20) :5945-5953

[5]

Barroso EM, J RAMAN SPECTR UNPUB

[6]

Bergholt MS, 2012, J BIOMED OPT, V17, DOI 10.1117/1.JBO.17.7.077002

[7]

Bilodeau EA, 2011, HEAD NECK PATHOL, V5, P2016

[8] The clinical significance of the positive surgical margin in oral cancer [J].

Binahmed, Abdulaziz ;

Nason, Richard W. ;

Abdoh, Ahmed A. .

ORAL ONCOLOGY, 2007, 43 (08) :780-784

[9] Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma [J].

Brown, JS ;

Kalavrezos, N ;

D'Souza, J ;

Lowe, D ;

Magennis, P ;

Woolgar, JA .

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2002, 40 (04) :275-284

[10] PROGNOSTIC AND THERAPEUTIC VALUE OF FROZEN SECTION DETERMINATIONS IN SURGICAL TREATMENT OF SQUAMOUS CARCINOMA OF HEAD AND NECK [J].

BYERS, RM ;

BLAND, KI ;

BORLASE, B ;

LUNA, M .

AMERICAN JOURNAL OF SURGERY, 1978, 136 (04) :525-528

← 1 2 3 4 5 →