Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor

被引：33

作者：

Izumi, T ^{[1
]}

Inoue, T ^{[1
]}

Kitaichi, Y ^{[1
]}

Nakagawa, S ^{[1
]}

Koyama, T ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Sapporo, Hokkaido 0608638, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 534卷 / 1-3期

关键词：

conditioned fear stress (CFS); citalopram; serotonin; anxiolytic; selective serotonin reuptake inhibitor (SSRI); c-Fos;

D O I：

10.1016/j.ejphar.2005.12.073

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of the present study was to elucidate the brain regions in which citalopram, a selective serotonin reuptake inhibitor (SSRI), exerts its anxiolytic effects in conditioned fear stress (CFS) in rats, an animal model of anxiety. The effect of citalopram on CFS-induced c-Fos expression was investigated using immunohistochemistry. Systemic administration of citalopram attenuated contextual CFS-induced c-Fos expression in the secondary motor cortex, primary somatosensory cortex, and basolateral nucleus of the amygdala. Among these regions the basolateral nucleus of the amygdala is a likely candidate region in which citalopram exerts its anxiolytic effect. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：129 / 132

页数：4

共 19 条

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