Cyanide as a Powerful Catalyst for Facile Preparation of 2-Substituted Benzoxazoles via Aerobic Oxidation

被引：92
作者：
Cho, Yeon Ho [1 ]
Lee, Chun-Young [1 ]
Ha, Deok-Chan [1 ]
Cheon, Cheol-Hong [1 ]
机构：
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 16期
基金：
新加坡国家研究基金会;
关键词：
aerobic oxidation; benzothiazoles; benzoxazoles; cyanide; one-pot protocol; PHENOLIC SCHIFF-BASES; EFFICIENT; 2-ARYLBENZOXAZOLES; BENZOTHIAZOLES; CYCLIZATION; BENZIMIDAZOLES;
D O I：
10.1002/adsc.201200684
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.
引用
收藏
页码：2992 / 2996
页数：5
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