Coronary Microvascular Function and Beyond: The Crosstalk between Hormones, Cytokines, and Neurotransmitters

被引：13
作者：
Dal Lin, Carlo [1 ]
Tona, Francesco [1 ]
Osto, Elena [2 ,3 ]
机构：
[1] Univ Padua, Dept Cardiac Thoracic & Vasc Sci, I-35100 Padua, Italy
[2] Univ Zurich, Ctr Mol Cardiol, CH-8091 Zurich, Switzerland
[3] Univ Zurich Hosp, Dept Cardiol, Univ Heart Ctr, CH-8091 Zurich, Switzerland
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2015年 / 2015卷
关键词：
TRANSTHORACIC DOPPLER-ECHOCARDIOGRAPHY; MYOCARDIAL BLOOD-FLOW; VASCULAR ENDOTHELIAL-CELLS; SYMPATHETIC-NERVOUS-SYSTEM; PARATHYROID-HORMONE; CARDIOVASCULAR-SYSTEM; MENTAL STRESS; NITRIC-OXIDE; INSULIN-RESISTANCE; VELOCITY RESERVE;
D O I：
10.1155/2015/312848
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Beyond its hemodynamic function, the heart also acts as a neuroendocrine and immunoregulatory organ. A dynamic communication between the heart and other organs takes place constantly to maintain cardiovascular homeostasis. The current understanding highlights the importance of the endocrine, immune, and nervous factors to fine-tune the crosstalk of the cardiovascular system with the entire body. Once disrupted, this complex interorgan communication may promote the onset and the progression of cardiovascular diseases. Thus, expanding our knowledge on how these factors influence the cardiovascular system can lead to novel therapeutic strategies to improve patient care. In the present paper, we review novel concepts on the role of endocrine, immune, and nervous factors in the modulation of microvascular coronary function.
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页数：17
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