HISTOPATHOLOGICAL EVALUATION OF Glycyrrhiza glabra ON ASPIRIN INDUCED GASTRIC ULCER IN MICE

Non-steroidal anti-inflammatory drugs (NSAIDs) have been frequently used for their anti-inflammatory, antipyretic and analgesic effects. Despite of such actions, these drugs also cause gastrotintestinal injury and produce gastric ulcers. In current study, antiulcer activity of Glycyrrhiza glabra was evaluated in adult male albino mice. Gastric ulcer was induced by administrating the high dose of aspirin to male adult albino mice. Treatment protocol was made for seven days. Group 1 was fed on normal diet, group 2 was given aspirin and group 3 was provided with standard treatment for ulcer, omeprazole along with aspirin. While groups 4, 5 and 6 were administered G. glabra roots powder at 250, 500 and 750 mg/kg body weight respectively, together with aspirin. Histopathological analysis was carried out to determine the gastroprotective activity of G. glabra. The results suggest that G. glabra has potent gastroprotective effect at highest dose.