The multifaceted roles of Eph/ephrin signaling in breast cancer

被引：49
作者：
Kaenel, Philip [1 ]
Mosimann, Mischa [1 ]
Andres, Anne-Catherine [1 ]
机构：
[1] Univ Bern, Dept Clin Res, Bern, Switzerland
来源：
CELL ADHESION & MIGRATION | 2012年 / 6卷 / 02期
基金：
瑞士国家科学基金会;
关键词：
angiogenesis; differentiation; EphA; EphB; mammary gland; stem cells; tumorigenesis; RECEPTOR TYROSINE KINASE; MAMMARY BRANCHING MORPHOGENESIS; NEURAL PROGENITOR CELLS; EPH RECEPTORS; TUMOR-CELLS; CARCINOMA CELLS; METASTATIC PROGRESSION; EPITHELIAL DEVELOPMENT; INTESTINAL EPITHELIUM; EPHRIN-B2; EXPRESSION;
D O I：
10.4161/cam.20154
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In this review we concentrate on their involvement in the normal and carcinogenic development of the breast. In this context we summarize their multi-faceted functions as tumor suppressors, tumor promoters, angiogenic inducers and regulators of stem cell homeostasis.
引用
收藏
页码：138 / 147
页数：10
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