Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells
被引:12
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作者:
Wu, Cheng-Zhu
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Anhui Prov Biochem Pharmaceut Engn Technol Res Ct, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Wu, Cheng-Zhu
[1
,2
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Gao, Mei-Jia
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Gao, Mei-Jia
[1
]
Chen, Jie
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Chen, Jie
[1
]
Sun, Xiao-Long
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Sun, Xiao-Long
[1
]
Zhang, Ke-Yi
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Zhang, Ke-Yi
[1
]
Dai, Yi-Qun
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Dai, Yi-Qun
[1
]
Ma, Tao
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Ma, Tao
[1
]
Li, Hong-Mei
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Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Anhui Prov Biochem Pharmaceut Engn Technol Res Ct, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Li, Hong-Mei
[1
,2
]
Zhang, Yu-Xin
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Anhui Prov Biochem Pharmaceut Engn Technol Res Ct, Bengbu 233030, Peoples R China
Bengbu Med Coll, Sch Lab Med, 2600 Donghai Rd, Bengbu 233030, Peoples R ChinaBengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Zhang, Yu-Xin
[2
,3
]
机构:
[1] Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
[2] Anhui Prov Biochem Pharmaceut Engn Technol Res Ct, Bengbu 233030, Peoples R China
[3] Bengbu Med Coll, Sch Lab Med, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Standardized treatment guidelines and effective drugs are not available for human triple-negative breast cancer (TNBC). Many efforts have recently been exerted to investigate the efficacy of natural compounds as anticancer agents owing to their low toxicity. However, no study has examined the effects of isobavachalcone (IBC) on the programmed cell death (PCD) of human triple-negative breast MDA-MB-231 cancer cells. In this study, IBC substantially inhibited the proliferation of MDA-MB-231 cells in concentration- and time-dependent manners. In addition, we found that IBC induced multiple cell death processes, such as apoptosis, necroptosis, and autophagy in MDA-MB-231 cells. The initial mechanism of IBC-mediated cell death in MDA-MB-231 cells involves the downregulation of Akt and p-Akt-473, an increase in the Bax/Bcl-2 ratio, and cleaved caspases-3 induced apoptosis; the upregulation of RIP3, p-RIP3 and MLKL induced necroptosis; as well as a simultaneous increase in LC3-II/I ratio induced autophagy. In addition, we observed that IBC induced mitochondrial dysfunction, thereby decreasing cellular ATP levels and increasing reactive oxygen species accumulation to induce PCD. These results suggest that IBC is a promising lead compound with anti-TNBC activity.
机构:
Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Kwak, Jin Ho
Park, Jun Yeon
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Gachon Univ, Coll Korean Med, Songnam 461701, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Park, Jun Yeon
Lee, Dahae
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Gachon Univ, Coll Korean Med, Songnam 461701, South Korea
Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 660758, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Lee, Dahae
Kwak, Jae Young
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Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Kwak, Jae Young
Park, Eun Hwa
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Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Park, Eun Hwa
Kim, Ki Hyun
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Sungkyunkwan Univ, Sch Pharm, Nat Prod Res Lab, Suwon 440746, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Kim, Ki Hyun
Park, Hye-Jin
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Gachon Univ, Coll BioNano Technol, Dept Food Sci & Biotechnol, Sungnam Gyeonggi Do 461701, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Park, Hye-Jin
Kim, Hyun Young
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Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 660758, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Kim, Hyun Young
Jang, Hyuk Jai
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Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Jang, Hyuk Jai
Ham, Jungyeob
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Korea Inst Sci & Technol, Inst Nat Prod Res, Kangnung 210340, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Ham, Jungyeob
Hwang, Gwi Seo
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Gachon Univ, Coll Korean Med, Songnam 461701, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Hwang, Gwi Seo
Yamabe, Noriko
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Gachon Univ, Coll Korean Med, Songnam 461701, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
Yamabe, Noriko
Kang, Ki Sung
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Gachon Univ, Coll Korean Med, Songnam 461701, South KoreaUniv Ulsan, Coll Med, Gangneung Asan Hosp, Dept Surg, Kangnung 210711, South Korea
机构:
Yijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R ChinaYijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R China
Luo, Can
Wang, Yu
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Wannan Med Coll, Dept Oncol, Wuhu 241001, Anhui, Peoples R ChinaYijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R China
Wang, Yu
Wei, Cheng
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Wannan Med Coll, Dept Oncol, Wuhu 241001, Anhui, Peoples R ChinaYijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R China
Wei, Cheng
Chen, Yuxin
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机构:
Soochow Univ, Gaoyou Hosp, Gaoyou Peoples Hosp, Dept Oncol, Gaoyou 225600, Jiangsu, Peoples R ChinaYijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R China
Chen, Yuxin
Ji, Zhaoning
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机构:
Yijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R ChinaYijishan Hosp, Wannan Med Coll, Dept Oncol, 2 Zheshan West Rd, Wuhu 241001, Anhui, Peoples R China