Seasonal variability in spontaneous cervical artery dissection

被引:40
作者
Paciaroni, M
Georgiadis, D
Arnold, M
Gandjour, J
Keseru, B
Fahrni, G
Caso, V
Baumgartner, RW
机构
[1] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland
[2] Univ Hosp Perugia, Stroke Unit, Perugia, Italy
[3] Univ Hosp Bern, Dept Neurol, CH-3010 Bern, Switzerland
关键词
D O I
10.1136/jnnp.2005.077073
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined the seasonal variability of spontaneous cervical artery dissection (sCAD) by analysing prospectively collected data from 352 patients with 380 sCAD ( 361 symptomatic sCAD; 305 carotid and 75 vertebral artery dissections) admitted to two university hospitals with a catchment area of 2 200 000 inhabitants between 1985 and 2004. Presenting symptoms and signs of the 380 sCAD were ischaemic stroke in 241 (63%), transient ischaemic attack in 40 (11%), retinal ischemia in seven (2%), and nonischaemic in 73 (19%) cases; 19 (5%) were asymptomatic sCAD. A seasonal pattern, with higher frequency of sCAD in winter (31.3%; 95% confidence interval (CI): 26.5 to 36.4; p = 0.021) compared to spring (25.5%; 95% CI: 21.1 to 30.3), summer (23.5%; 95% CI: 19.3 to 28.3), and autumn (19.7%; 95% CI: 15.7 to 24.1) was observed. Although the cause of seasonality in sCAD is unclear, the winter peaks of infection, hypertension, and aortic dissection suggest common underlying mechanisms.
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页码:677 / 679
页数:3
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