Women's posttraumatic stress symptoms and autism spectrum disorder in their children

被引：30

作者：

Roberts, Andrea L. ^{[1
]}

Koenen, Karestan C. ^{[2
]}

Lyall, Kristen ^{[3
,4
]}

Ascherio, Alberto ^{[3
,5
]}

Weisskopf, Marc G. ^{[5
,6
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

来源：

RESEARCH IN AUTISM SPECTRUM DISORDERS | 2014年 / 8卷 / 06期

关键词：

Autism spectrum disorder; Posttraumatic stress disorder; Gestational effects; CHILDHOOD GENDER NONCONFORMITY; ANTENATAL MATERNAL ANXIETY; PSYCHIATRIC-DISORDERS; PRENATAL EXPOSURE; PARENTING STRESS; VIETNAM VETERANS; ELEVATED RISK; MOTHERS; ABUSE; LONELINESS;

D O I：

10.1016/j.rasd.2014.02.004

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

Maternal posttraumatic stress disorder (PTSD) may be associated with autism spectrum disorder (ASD) in offspring through multiple pathways: maternal stress may affect the fetus; ASD in children may increase risk of PTSD in mothers; and the two disorders may share genetic risk. Understanding whether maternal PTSD is associated with child's ASD is important for clinicians treating children with ASD, as PTSD in parents is associated with poorer family functioning. We examined the association of maternal PTSD with offspring ASD in a large US cohort (N ASD cases = 413, N controls = 42,868). Mother's PTSD symptoms were strongly associated with child's ASD (RR 4-5 PTSD symptoms = 1.98, 95% CI = 1.39, 2.81; RR 6-7 symptoms = 2.89, 95% CI = 2.00, 4.18). Clinicians treating persons with ASD should be aware of elevated risk of PTSD in the mother. Genetic studies should investigate PTSD risk alleles in relation to ASD. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：608 / 616

页数：9

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