A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA: Characterization and pharmaceutical applications

A composite electrochemiluminescence (ECL) sensor was constructed by electrochemical polymerization of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) and tris(2,2'-bipyridyl) ruthenium(II), [Ru (bpy)(3)](2+), from their aqueous solutions at glassy carbon electrode (GCE). The proposed one-step electrochemical synthesis of the composite film (Ru/PAHNSA/GCE) provides a stable and reactive luminescent for the quantification of chlorpheniramine maleate (CPM) in its pharmaceutical preparations. The properties and the structure of the modified surface were studied using typical voltammetric, Electrochemical Impedance Spectroscopy (EIS), X-Ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) methods. The intensity of the ECL as a function of [CPM] is linear for the range between 0.2 and 32 mu g mL(-1) with a detection limit of 0.023 mu g mL(-1). The performance of the sensor was tested in the presence of interference species and for real sample analysis under optimal conditions. (C) 2015 Elsevier Ltd. All rights reserved.