Microwave-assisted Synthesis of Arene Ru(II) Complex [(η6-C6H6)Ru(H2iiP)Cl]Cl in SiC Vessel

被引：3
作者：
Wu Qiong [1 ]
Mei Wen-Jie [1 ,2 ]
Wu Wei-Li [1 ]
Chen Yan-Hua [1 ]
Zeng Ling-Li [1 ]
Zheng Wen-Jie [2 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
[2] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2013年 / 34卷 / 08期
关键词：
2-Indole-3-imidazole [4, 5-f] [1,10] phenanthroline (H(2)iiP); Arene Ru(II) complex; SiC vessel; Microwave-assisted synthesis; Antitumor; SILICON-CARBIDE; RUTHENIUM; REACTIVITY; CHEMISTRY; APOPTOSIS; COMPOUND;
D O I：
10.7503/cjcu20121112
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Arene Ru(II) complex [(eta(6)-C6H6)Ru(H(2)iip)Cl]Cl (1) was synthesized using [(eta(6)-C6H6) center dot RuCl2](2) and 2-indole-3-imidazole[4,5-f][1,10] phenanthroline(H(2)iiP) as raw material under microwave irradiation. The target compound was characterized by means of elemental analysis, ESI-MS, IR and NMR. The best craft condition determined by orthogonal test is that reactant molar ratio of 1. 0 : 2. 2, the reaction temperature of 90 degrees C and the microwave irradiation time of 30 min. Then the average yield of 96. 0% and RSD of 1. 28% confirmed that microwave-assisted synthesis of arene Ru() complex in SIC vessel gives a good stability and reiteration. The antitumor activity of arene Ru (II) complex 1 was determined by MTT assay and the results showed that complex 1 could selectively inhibit the growth of MCF-7, indicating its potential utility in chemotherapy.
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收藏
页码：1863 / 1867
页数：5
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