Down-regulation of miR-122 after transplantation of mesenchymal stem cells in acute liver failure in mice model

被引:9
作者
Fathi-Kazerooni, Mina [1 ]
Kazemnejad, Somaieh [2 ]
Khanjani, Sayeh [2 ]
Saltanatpour, Zohreh [1 ]
Tavoosidana, Gholamreza [1 ]
机构
[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, POB 1417755469, Tehran, Iran
[2] ACECR, Avicenna Res Inst, Reprod Biotechnol Res Ctr, Tehran, Iran
关键词
Liver injury; Micro-RNA; Regenerative medicine; Menstrual blood stem cells; Bone marrow stem cells; CIRCULATING MICRORNAS; INJURY; DIFFERENTIATION; INFLAMMATION; BIOMARKERS; EXPRESSION;
D O I
10.1016/j.biologicals.2019.02.002
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This study investigated the correlation between the hepatic level of miR-122 and the extent of liver tissue regeneration in CCl4 induced liver injury mice model following transplantation of menstrual blood-(MenSCs) and bone marrow-derived stem cells (BMSCs). Hepatic miR-122 levels were significantly up-regulated following administration of CCl4 (P < 0.01). The significant positive correlations were observed between hepatic miR-122 and biochemical serum markers and the severity of liver injury in histopathological assessments (P < 0.01). Following stem cell therapy, all cell treated groups showed a significant down-regulation in miR-122 that was significantly correlated with improvement in histopathological features and biochemical markers (P < 0.01). Furthermore, the hepatic level of miR-122 was lower in the MenSCs-treated group compared with the BMSCs-treated group (P < 0.01) and in HPL cells-treated groups in reference to undifferentiated cells-treated groups (P < 0.05). These data suggest that miR-122 could be used as a potential predictor of outcome of liver injury after mesenchymal stem cell transplantation.
引用
收藏
页码:64 / 72
页数:9
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