CLAUDINS AND THE MODULATION OF TIGHT JUNCTION PERMEABILITY

被引：1046
作者：
Guenzel, Dorothee
Yu, Alan S. L. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Kidney Inst, Kansas City, KS 66160 USA
来源：
PHYSIOLOGICAL REVIEWS | 2013年 / 93卷 / 02期
基金：
美国国家卫生研究院;
关键词：
BLOOD-BRAIN-BARRIER; GROWTH-FACTOR-BETA; INTEGRAL MEMBRANE-PROTEINS; THICK ASCENDING LIMB; NF-KAPPA-B; INTESTINAL EPITHELIAL-CELLS; TISSUE-SPECIFIC EXPRESSION; 1ST EXTRACELLULAR DOMAIN; CANINE KIDNEY-CELLS; SUBCELLULAR-LOCALIZATION;
D O I：
10.1152/physrev.00019.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Gunzel D, Yu ASL. Claudins and the Modulation of Tight Junction Permeability. Physiol Rev 93: 525-569, 2013; doi:10.1152/physrev.00019.2012.-Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.
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收藏
页码：525 / 569
页数：45
相关论文
共 429 条
  • [51] Transmembrane proteins of tight junctions
    Chiba, Hideki
    Osanai, Makoto
    Murata, Masaki
    Kojima, Takashi
    Sawada, Norimasa
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (03): : 588 - 600
  • [52] Identification of the gene encoding brain cell membrane protein I (BCMPI), a putative four-transmembrane protein distantly related to the peripheral myelin protein 22 / epithelial membrane proteins and the claudins
    Christophe-Hobertus C.
    Szpirer C.
    Guyon R.
    Christophe D.
    [J]. BMC Genomics, 2 (1)
  • [53] Cieply B, 2012, CANC RES
  • [54] MORPHOLOGICAL FACTORS INFLUENCING TRANS-EPITHELIAL PERMEABILITY - MODEL FOR RESISTANCE OF ZONULA-OCCLUDENS
    CLAUDE, P
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 1978, 39 (2-3) : 219 - 232
  • [55] FRACTURE FACES OF ZONULAE OCCLUDENTES FROM TIGHT AND LEAKY EPITHELIA
    CLAUDE, P
    GOODENOUGH, DA
    [J]. JOURNAL OF CELL BIOLOGY, 1973, 58 (02) : 390 - 400
  • [56] Claudins create charge-selective channels in the paracellular pathway between epithelial cells
    Colegio, OR
    Van Itallie, CM
    McCrea, HJ
    Rahner, C
    Anderson, JM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 283 (01): : C142 - C147
  • [57] Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
    Colegio, OR
    Van Itallie, C
    Rahner, C
    Anderson, JM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 284 (06): : C1346 - C1354
  • [58] Role of claudin interactions in airway tight junctional permeability
    Coyne, CB
    Gambling, TM
    Boucher, RC
    Carson, JL
    Johnson, LG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 285 (05) : L1166 - L1178
  • [59] Residues in a Highly Conserved Claudin-1 Motif Are Required for Hepatitis C Virus Entry and Mediate the Formation of Cell-Cell Contacts
    Cukierman, Lisa
    Meertens, Laurent
    Bertaux, Claire
    Kajumo, Francis
    Dragic, Tatjana
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (11) : 5477 - 5484
  • [60] Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells
    D'Souza, T
    Agarwal, R
    Morin, PJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (28) : 26233 - 26240
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