CLAUDINS AND THE MODULATION OF TIGHT JUNCTION PERMEABILITY

被引：1080
作者：
Guenzel, Dorothee
Yu, Alan S. L. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Kidney Inst, Kansas City, KS 66160 USA
来源：
PHYSIOLOGICAL REVIEWS | 2013年 / 93卷 / 02期
基金：
美国国家卫生研究院;
关键词：
BLOOD-BRAIN-BARRIER; GROWTH-FACTOR-BETA; INTEGRAL MEMBRANE-PROTEINS; THICK ASCENDING LIMB; NF-KAPPA-B; INTESTINAL EPITHELIAL-CELLS; TISSUE-SPECIFIC EXPRESSION; 1ST EXTRACELLULAR DOMAIN; CANINE KIDNEY-CELLS; SUBCELLULAR-LOCALIZATION;
D O I：
10.1152/physrev.00019.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Gunzel D, Yu ASL. Claudins and the Modulation of Tight Junction Permeability. Physiol Rev 93: 525-569, 2013; doi:10.1152/physrev.00019.2012.-Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.
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页码：525 / 569
页数：45
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