Clinical applications of gut microbiota in cancer biology

被引：70
作者：
Wong, Sunny H. [1 ,2 ,3 ]
Kwong, Thomas N. Y. [1 ,2 ]
Wu, Chun-Ying [4 ,5 ,6 ,7 ]
Yu, Jun [1 ,2 ,3 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Hong Kong, Peoples R China
[3] CUHK Shenzhen Res Inst, Shenzhen, Peoples R China
[4] Taipei Vet Gen Hosp, Dept Med Res, Div Translat Res, Taipei 11217, Taiwan
[5] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
[6] China Med Univ, Coll Publ Hlth, Taichung, Taiwan
[7] China Med Univ, Grad Inst Clin Med, Taichung, Taiwan
来源：
SEMINARS IN CANCER BIOLOGY | 2019年 / 55卷
关键词：
Microbiota; Metagenomics; Cancer; Host-microbe interaction; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; PERIODONTAL-DISEASE; HELICOBACTER-PYLORI; INTESTINAL MICROBIOTA; COLONIZATION RESISTANCE; PANCREATIC-CANCER; ORAL MICROBIOME; GASTRIC-CANCER; GERM-FREE;
D O I：
10.1016/j.semcancer.2018.05.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The involvement of microorganisms in cancer has been increasing recognized. Collectively, microorganisms have been estimated to account for similar to 20% of all cancers worldwide. Recent advances in metagenomics and bioinformatics have provided new insights on the microbial ecology in different tumors, pinpointing the roles of microorganisms in cancer formation, development and response to treatments. Furthermore, studies have emphasized the importance of host-microbial and inter-microbial interactions in the cancer microbiota. These studies have not only revolutionized our understanding of cancer biology, but also opened up new opportunities for cancer prevention, diagnosis, prognostication and treatment. This review article aims to summarize the microbiota in various cancers and their treatments, and explore clinical applications for such relevance.
引用
收藏
页码：28 / 36
页数：9
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