Scaffold Fabrication Techniques of Biomaterials for Bone Tissue Engineering: A Critical Review

被引：49

作者：

Bhushan, Sakchi ^{[1
]}

Singh, Sandhya ^{[1
]}

Maiti, Tushar Kanti ^{[2
]}

Sharma, Chhavi ^{[2
]}

Dutt, Dharm ^{[1
]}

Sharma, Shubham ^{[3
,4
]}

Li, Changhe ^{[4
]}

Tag Eldin, Elsayed Mohamed ^{[5
]}

机构：

[1] IIT Roorkee, Dept Paper Technol, Saharanpur 247001, India

[2] IIT Roorkee, Dept Polymer & Proc Engn, Saharanpur 247001, India

[3] Chandigarh Univ, Univ Ctr Res & Dev, Mech Engn Dept, Mohali 140413, India

[4] Qingdao Univ Technol, Sch Mech & Automot Engn, Qingdao 266520, Peoples R China

[5] Future Univ Egypt, Fac Engn & Technol, New Cairo 11835, Egypt

来源：

BIOENGINEERING-BASEL | 2022年 / 9卷 / 12期

关键词：

bone tissue engineering; fabrication; biocompatibility; electrohydrodynamic behavior; additive manufacturing techniques; 4D printing; clinical trials;

D O I：

10.3390/bioengineering9120728

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bone tissue engineering (BTE) is a promising alternative to repair bone defects using biomaterial scaffolds, cells, and growth factors to attain satisfactory outcomes. This review targets the fabrication of bone scaffolds, such as the conventional and electrohydrodynamic techniques, for the treatment of bone defects as an alternative to autograft, allograft, and xenograft sources. Additionally, the modern approaches to fabricating bone constructs by additive manufacturing, injection molding, microsphere-based sintering, and 4D printing techniques, providing a favorable environment for bone regeneration, function, and viability, are thoroughly discussed. The polymers used, fabrication methods, advantages, and limitations in bone tissue engineering application are also emphasized. This review also provides a future outlook regarding the potential of BTE as well as its possibilities in clinical trials.

引用

页数：39

共 223 条

[1] Poly (glycerol sebacate) and polyhydroxybutyrate electrospun nanocomposite facilitates osteogenic differentiation of mesenchymal stem cells [J].

Abazari, Mohammad Foad ;

Karizi, Shohreh Zare ;

Samadian, Hadi ;

Nasiri, Navid ;

Askari, Hassan ;

Asghari, Matin ;

Frootan, Fateme ;

Bakhtiari, Hadi ;

Mahboudi, Hossein ;

Mansouri, Vahid .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 66

[2] Porous scaffolds for bone regeneration [J].

Abbasi, Naghmeh ;

Hamlet, Stephen ;

Love, Robert M. ;

Nguyen, Nam-Trung .

JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES, 2020, 5 (01) :1-9

[3]

Agarwal K., 2020, P 2017 INT SOL FREEF, P2376

[4] Hydrogel: Preparation, characterization, and applications: A review [J].

Ahmed, Enas M. .

JOURNAL OF ADVANCED RESEARCH, 2015, 6 (02) :105-121

[5] Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering [J].

Akbarzadeh, Rosa ;

Yousefi, Azizeh-Mitra .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2014, 102 (06) :1304-1315

[6] Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair [J].

Alcala-Orozco, Cesar R. ;

Mutreja, Isha ;

Cui, Xiaolin ;

Hooper, Gary J. ;

Lim, Khoon S. ;

Woodfield, Tim B. F. .

BONE, 2022, 154

[7] Hydroxyapatite mixed-electro discharge formation of bioceramic Lakargiite (CaZrO3) on Zr-Cu-Ni-Ti-Be for orthopedic application [J].

Aliyu, Abdul Azeez Abdu ;

Abdul-Rani, Ahmad Majdi ;

Ginta, Turnad Lenggo ;

Rao, T. V. V. L. N. ;

Selvamurugan, Nagarajan ;

Roy, Sandipan .

MATERIALS AND MANUFACTURING PROCESSES, 2018, 33 (16) :1734-1744

[8]

Amini Ami R., 2012, Critical Reviews in Biomedical Engineering, V40, P363

[9]

Annabi N, 2010, TISSUE ENG PART B-RE, V16, P371, DOI 10.1089/ten.TEB.2009.0639

[10] Evaluation of the effects of starch on polyhydroxybutyrate electrospun scaffolds for bone tissue engineering applications [J].

Asl, Maryam Abdollahi ;

Karbasi, Saeed ;

Beigi-Boroujeni, Saeed ;

Benisi, Soheila Zamanlui ;

Saeed, Mahdi .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 191 :500-513

← 1 2 3 4 5 6 7 8 9 10 →