Accounting for Post-Transcriptional Regulation in Boolean Networks Based Regulatory Models

被引：0

作者：

Benso, Alfredo ^{[1
]}

Di Carlo, Stefano ^{[1
]}

Rehman, Hafeez Ur ^{[1
]}

Politano, Gianfranco ^{[1
]}

Savino, Alessandro ^{[1
]}

Squillero, Giovanni ^{[1
]}

Vasciaveo, Alessandro ^{[1
]}

Benedettini, Stefano ^{[2
]}

机构：

[1] Politecn Torino, Control & Comp Engn Dept, Turin, Italy

[2] European Ctr Living Technol, Venice, Italy

来源：

PROCEEDINGS IWBBIO 2013: INTERNATIONAL WORK-CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING | 2013年

关键词：

miRNA; Gene Regulatory Networks; post-transcriptional regulation; Boolean Networks; Complex Systems; Network Analysis;

D O I：

暂无

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Boolean Networks are emerging as a simple yet powerful formalism to model and study Gene Regulatory Networks. Nevertheless, the most widely used Boolean Network-based models do not include any post-transcriptional regulation mechanism. In this paper we discuss how the post-transcriptional regulation mechanism mediated by miRNAs can be included in a Boolean Network based model. This contribution constitutes a key preparatory step in the study of the topological and structural role of miRNAs in complex regulatory networks.

引用

页码：397 / +

页数：3

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