Review of the safety and efficacy of voriconazole

被引：3
作者：
Hoffman, HL [1 ]
Rathbun, RC [1 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Oklahoma City, OK 73190 USA
来源：
EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2002年 / 11卷 / 03期
关键词：
antifungal; triazole; voriconazole;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Voriconazole is a new, triazole antifungal agent structurally related to fluconazole, but with improved potency and spectrum of activity. Voriconazole: has good in vitro activity against Candida species, Cryptococcus neoformans, Aspergillus spp. and other mould spp. Initial clinical studies and case reports demonstrate efficacy with voriconazole against invasive aspergillosis and infections caused by C. neoformans, Scedosporium apiospermum, Blastomyces dermatitidis, Coccidioides immitis and Histoplasma capsulatum. Voriconazole is available both as oral and iv. preparations and exhibits complex pharmacokinetics. This drug is metabolised by the cytochrome (CYP) P450 enzyme system and therefore, has potential drug interactions. This review evaluates the current literature regarding the safety and efficacy of voriconazole.
引用
收藏
页码：409 / 429
页数：21
相关论文
共 119 条
  • [1] In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B
    Abraham, OC
    Manavathu, EK
    Cutright, JL
    Chandrasekar, PH
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 33 (01) : 7 - 11
  • [2] ALCALA L, 2000, 40 INT C ANT AG CHEM
  • [3] DIGOXIN-ITRACONAZOLE INTERACTION
    ALDERMAN, CP
    JERSMANN, HPA
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 1993, 159 (11-12) : 838 - 839
  • [4] A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients
    Ally, R
    Schürmann, D
    Kreisel, W
    Carosi, G
    Aguirrebengoa, K
    Dupont, B
    Hodges, M
    Troke, P
    Romero, AJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2001, 33 (09) : 1447 - 1454
  • [5] In vitro studies of two triazole antifungal agents (Voriconazole [UK-109,496] and fluconazole) against Candida species
    Barry, AL
    Brown, SD
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) : 1948 - 1949
  • [6] Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation
    Bielorai, B
    Toren, A
    Wolach, B
    Mandel, M
    Golan, H
    Neumann, Y
    Kaplinisky, C
    Weintraub, M
    Keller, N
    Amariglio, N
    Paswell, J
    Rechavi, G
    [J]. BONE MARROW TRANSPLANTATION, 2000, 26 (09) : 1025 - 1028
  • [7] Black DJ, 1996, DRUG METAB DISPOS, V24, P422
  • [8] BLUMMER JL, 2001, 41 INT C ANT AG CHEM
  • [9] In vitro activities of four novel triazoles against Scedosporium spp.
    Carrillo, AJ
    Guarro, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) : 2151 - 2153
  • [10] Centre for Drug Evaluation and Research, 2017, CLIN MICROBIOL REV
12345678910