Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

被引：75

作者：

Nevola, Laura ^{[1
]}

Martin-Quiros, Andres ^{[2
]}

Eckelt, Kay ^{[2
]}

Camarero, Nuria ^{[2
]}

Tosi, Sebastien ^{[1
]}

Llobet, Artur ^{[3
]}

Giralt, Ernest ^{[1
,4
]}

Gorostiza, Pau ^{[2
]}

机构：

[1] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain

[2] Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain

[3] Bellvitge Biomed Res Inst IDIBELL, Bellvitge, Spain

[4] Univ Barcelona, E-08007 Barcelona, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 30期

基金：

欧洲研究理事会;

关键词：

clathrin-mediated endocytosis; optopharmacology; peptides; photoswitches; protein-protein interactions; CYCLIC-PEPTIDES; PHOTO-CONTROL; COATED PITS; DYNAMIN; AZOBENZENE; SWITCHES; HELIX; SELECTION; CELLS;

D O I：

10.1002/anie.201303324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Control of membrane traffic: Photoswitchable inhibitors of protein-protein interactions were applied to photoregulate clathrin-mediated endocytosis (CME) in living cells. Traffic light (TL) peptides acting as "stop" and "go" signals for membrane traffic can be used to dissect the role of CME in receptor internalization and in cell growth, division, and differentiation. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7704 / 7708

页数：5

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