NK cell-released exosomes Natural nanobullets against tumors

被引：71
作者：
Fais, Stefano [1 ]
机构：
[1] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, Unit Antitumor Drugs, I-00161 Rome, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期
关键词：
exosomes; natural killer; nanomedicine; perorin; theranostic; SURVEILLANCE; PERFORIN;
D O I：
10.4161/onci.22337
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived exosomes might constitute a new promising therapeutic tool.
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