C-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis

被引：30

作者：

Guiet, C

Silvestri, E

De Smaele, E

Franzoso, G

Vito, P

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

[2] Univ Chicago, Ben May Inst Canc Res, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2002年 / 9卷 / 02期

关键词：

TNF; apoptosis; c-FLIP; TRAF-2;

D O I：

10.1038/sj/cdd/4400947

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For the past 20 years, it has been known that preparations of Tumor Necrosis Factor alpha (TNF) fail to induce apoptosis due to cytoprotective responses that render cells resistant to its cytotoxic activity. Here we show that TRAF-2(-/-) embryonic fibroblasts express reduced levels of the anti-apoptotic molecule c-FLIP due to extensive degradation of the protein. Reconstitution of TRAF-2(-/-) EF with c-FLIP is sufficient for resistance to TNF toxicity. Our results strengthen the role of c-FLIP in protecting cells from the cytotoxic effect of TNF and have implication for the treatment of inflammatory and proliferative disorders.

引用

收藏

页码：138 / 144

页数：7

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