Purpose of review The present review summarizes the association of the different histotypes of Epstein-Barr virus (EBV)associated lymphomas with known genetic lesions and/or oncogenic viruses. A more comprehensive understanding of the complex interplay existing between genetic abnormalities of tumor cells and the viral contribution to the development of EBV-associated lymphomas is pivotal for the development of more effective treatments. Recent findings Recent evidence indicates that HIV may contribute to lymphomagenesis by acting directly on B lymphocytes as a critical microenvironmental factor. The pathogenesis of EBV-associated lymphomas in patients with HIV infection is considered the result of the concerted action of different factors, mainly including impaired immune surveillance, genetic alterations, and concomitant viral infection (EBV and HIV). Summary Immunodeficiency states usually increase susceptibility to cancer as a result of reduced immune surveillance and enhanced chances for virus-driven oncogenesis. Lymphoma remains the most frequent neoplastic cause of death among patients infected with HIV. Several of the HIV-associated lymphomas are related to EBV infection. EBV-associated lymphomas in patients infected with HIV are heterogeneous, not only pathologically but also in terms of pathogenetic pathways and cellular derivation.
机构:
Mem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Arvey, Aaron
;
Ojesina, Akinyemi I.
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机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Ojesina, Akinyemi I.
;
Pedamallu, Chandra Sekhar
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h-index: 0
机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Pedamallu, Chandra Sekhar
;
Ballon, Gianna
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机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Ballon, Gianna
;
Jung, Joonil
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机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Jung, Joonil
;
Duke, Fujiko
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机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Duke, Fujiko
;
Leoncini, Lorenzo
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机构:
Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, ItalyMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Leoncini, Lorenzo
;
De Falco, Giulia
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Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, ItalyMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
De Falco, Giulia
;
Bressman, Eric
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机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Bressman, Eric
;
Tam, Wayne
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机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Tam, Wayne
;
Chadburn, Amy
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机构:
Northwestern Univ, Dept Pathol, Chicago, IL 60611 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Chadburn, Amy
;
Meyerson, Matthew
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机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Meyerson, Matthew
;
Cesarman, Ethel
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h-index: 0
机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Arvey, Aaron
;
Ojesina, Akinyemi I.
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Ojesina, Akinyemi I.
;
Pedamallu, Chandra Sekhar
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Pedamallu, Chandra Sekhar
;
Ballon, Gianna
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Ballon, Gianna
;
Jung, Joonil
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Jung, Joonil
;
Duke, Fujiko
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Duke, Fujiko
;
Leoncini, Lorenzo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, ItalyMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Leoncini, Lorenzo
;
De Falco, Giulia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, ItalyMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
De Falco, Giulia
;
Bressman, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Bressman, Eric
;
Tam, Wayne
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Tam, Wayne
;
Chadburn, Amy
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pathol, Chicago, IL 60611 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Chadburn, Amy
;
Meyerson, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA
Meyerson, Matthew
;
Cesarman, Ethel
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA