Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice

被引：6

作者：

Zafiratos, Mark T. ^{[1
]}

Cottrell, Jonathan T. ^{[2
]}

Manam, Srikanth ^{[3
]}

Henderson, Kyle K. ^{[2
]}

Ramsey, Kyle H. ^{[2
,3
]}

Murthy, Ashlesh K. ^{[3
]}

机构：

[1] Midwestern Univ, Coll Hlth Sci, Downers Grove, IL 60515 USA

[2] Midwestern Univ, Chicago Coll Osteopath Med, Downers Grove, IL 60515 USA

[3] Midwestern Univ, Coll Vet Med, Glendale, AZ 85308 USA

来源：

MICROBES AND INFECTION | 2019年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Chlamydia pneumoniae; Atherosclerosis; Pathogenesis; Tumor necrosis factor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor 2; CD8(+) T-CELLS; TARGET; TNFR2;

D O I：

10.1016/j.micinf.2018.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The host immune responses that mediate Chlamydia-induced chronic disease sequelae are incompletely understood. The role of TNF-alpha, TNF receptor 1 (TNFR1), and TNF receptor 2 (TNFR2), in Chlamydia pneumoniae (CPN)-induced atherosclerosis was studied using the high-fat diet-fed male C57BL/6J mouse model. Following intranasal CPN infection, TNF-alpha knockout (KO), TNFR1 KO, TNFR2 KO, and TNFR 1/2 double-knockout, displayed comparable serum anti-chlamydial antibody response, splenic antigen-specific cytokine response, and serum cholesterol profiles compared to wild type (WT) animals. However, atherosclerotic pathology in each CPN-infected KO mouse group was reduced significantly compared to WT mice, suggesting that both TNFR1 and TNFR2 promote CPN-induced atherosclerosis. (C) 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：104 / 108

页数：5

共 15 条

[11] Tumor Necrosis Factor Alpha Production from CD8+ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection [J].

Murthy, Ashlesh K. ;

Li, Weidang ;

Chaganty, Bharat K. R. ;

Kamalakaran, Sangamithra ;

Guentzel, M. Neal ;

Seshu, J. ;

Forsthuber, Thomas G. ;

Zhong, Guangming ;

Arulanandam, Bernard P. .

INFECTION AND IMMUNITY, 2011, 79 (07) :2928-2935

[12] Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice [J].

Nicolaou, Alexandros ;

Zhao, Zhen ;

Northoff, Bernd H. ;

Sass, Kristina ;

Herbst, Andreas ;

Kohlmaier, Alexander ;

Chalaris, Athena ;

Wolfrum, Christian ;

Weber, Christian ;

Steffens, Sabine ;

Rose-John, Stefan ;

Teupser, Daniel ;

Holdt, Lesca M. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017, 37 (02) :247-+

[13] Animal models for Chlamydia pneumoniae infection [J].

Saikku, P ;

Laitinen, K ;

Leinonen, M .

ATHEROSCLEROSIS, 1998, 140 :S17-S19

[14] TNFR2: A Novel Target for Cancer Immunotherapy [J].

Vanamee, Eva S. ;

Faustman, Denise L. .

TRENDS IN MOLECULAR MEDICINE, 2017, 23 (11) :1037-1046

[15] CD8+ T cells mediate Chlamydia pneumoniae-induced atherosclerosis in mice [J].

Zafiratos, Mark T. ;

Manam, Srikanth ;

Henderson, Kyle K. ;

Ramsey, Kyle H. ;

Murthy, Ashlesh K. .

PATHOGENS AND DISEASE, 2015, 73 (07)

← 1 2 →