Enhancement Effect of Cytotoxicity Response of Silver Nanoparticles Combined with Thermotherapy on C6 Rat Glioma Cells

被引：22
|
作者：
Wang, Rui [1 ]
Chen, Chunmei [1 ]
Yang, Weizhong [1 ]
Shi, Songsheng [1 ]
Chen, Jing [1 ]
机构：
[1] Fujian Med Univ, Affiliated Union Hosp, Dept Neurosurg, Fuzhou 350001, Peoples R China
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2013年 / 13卷 / 06期
关键词：
Silver Nanoparticles; Hyperthermia; Thermosensitivity; Cancer Cells; GOLD NANOPARTICLES; DNA-DAMAGE; IN-VIVO; HYPERTHERMIA; NANOSILVER; NANOCOMPOSITE; RADIOTHERAPY; APOPTOSIS; CYCLE;
D O I：
10.1166/jnn.2013.7156
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present studies reveal that silver nanoparticles (AgNPs) can induce apoptosis and enhance radio-sensitivity on cancer cells. In this paper, we mainly investigated the effect of AgNPs on rat glionna C6 cells upon the combination treatment of hyperthermia treatment (HTT). AgNPs were synthesized by a polyol process and the mean size was 15 nm. The particles showed dose-dependent cytotoxicity on 06 cells from the experimental data. Besides, we found that heating cells could enhance the contents of cell uptake of AgNPs. From the survival curves, AgNPs showed the ability to enhance thermo-sensitivity on C6 cells. Our results revealed that AgNPs could have a potential application in enhancing effect on HTT induced killing of glioma cells.
引用
收藏
页码：3851 / 3854
页数：4
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