Structural basis of transcription:: α-Amanitin-RNA polymerase II cocrystal at 2.8 A resolution

被引：231
|
作者：
Bushnell, DA [1 ]
Cramer, P [1 ]
Kornberg, RD [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 03期
关键词：
D O I：
10.1073/pnas.251664698
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
引用
收藏
页码：1218 / 1222
页数：5
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