A New Alkenylphenol from the Propolis of Stingless Bee Trigona minor

被引：0

作者：

Hai Xuan Nguyen ^{[1
]}

Truong Nhat Van Do ^{[1
]}

Mai Thanh Thi Nguyen ^{[1
,2
]}

Phu Hoang Dang ^{[1
]}

Le Huu Tho ^{[1
]}

Awale, Suresh ^{[3
]}

Nhan Trung Nguyen ^{[1
,2
]}

机构：

[1] VNUHCM Univ Sci, Fac Chem, 227 Nguyen Van Cu St,Dist 5, Ho Chi Minh City, Vietnam

[2] VNUHCM Univ Sci, Canc Res Lab, 227 Nguyen Van Cu St,Dist 5, Ho Chi Minh City, Vietnam

[3] Univ Toyama, Inst Nat Med, Div Nat Drug Discovery, 2630 Sugitani, Toyama 9300194, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 01期

基金：

日本学术振兴会;

关键词：

Trigona minor; Stingless bee; Propolis; PANC-1; NDM; CONSTITUENTS; TOLERANCE; CELLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new alkenylphenol, 2-hydroxyl-6-(14'Z-nonadecenyl)benzoic acid (1), was isolated from the ethanolie extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with two known compounds (2 and 3). Their chemical structures were determined by extensive NMR spectroscopic analysis. All compounds were tested for preferential cytotoxicity against the PANC-1 human pancreatic cell line under nutrition-deprived conditions (NDM). Compound 1 exhibited the strongest preferential cytotoxicity, with a PC50 value of 2.4 mu M.

引用

页码：69 / 70

页数：2

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