(Ph)ighting Phages: How Bacteria Resist Their Parasites

被引：197

作者：

Rostol, Jakob T. ^{[1
]}

Marraffini, Luciano ^{[1
,2
]}

机构：

[1] Rockefeller Univ, Lab Bacteriol, 1230 York Ave, New York, NY 10065 USA

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

CELL HOST & MICROBE | 2019年 / 25卷 / 02期

关键词：

ABORTIVE INFECTION SYSTEM; MEMBRANE-PROTEIN; RNA CLEAVAGE; FOREIGN DNA; CRISPR RNA; IN-VITRO; IMMUNITY; ANTITOXIN; DEFENSE; TOXIN;

D O I：

10.1016/j.chom.2019.01.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacteria are under constant attack from bacteriophages (phages), bacterial parasites that are the most abundant biological entity on earth. To resist phage infection, bacteria have evolved an impressive arsenal of anti-phage systems. Recent advances have significantly broadened and deepened our understanding of how bacteria battle phages, spearheaded by new systems like CRISPR-Cas. This review aims to summarize bacterial anti-phage mechanisms, with an emphasis on the most recent developments in the field.

引用

页码：184 / 194

页数：11

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