Senegenin Attenuates Hepatic Ischemia-Reperfusion Induced Cognitive Dysfunction by Increasing Hippocampal NR2B Expression in Rats

被引：33

作者：

Xie, Weibin ^{[2
]}

Yang, Yan ^{[1
]}

Gu, Xiaoping ^{[1
]}

Zheng, Yaguo ^{[1
]}

Sun, Yu-e ^{[1
]}

Liang, Ying ^{[1
]}

Bo, Jinhua ^{[1
]}

Ma, Zhengliang ^{[1
]}

机构：

[1] Nanjing Univ, Coll Med, Affiliated Drum Tower Hosp, Dept Anesthesiol, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Drum Tower Clin Coll Chinese & Western Integrat M, Nanjing, Jiangsu, Peoples R China

来源：

PLOS ONE | 2012年 / 7卷 / 09期

关键词：

POLYGALA-TENUIFOLIA ROOT; LONG-TERM POTENTIATION; GENETIC ENHANCEMENT; NMDA RECEPTORS; MEMORY; TENUIGENIN; EXTRACT; DECLINE; MICE; SECRETION;

D O I：

10.1371/journal.pone.0045575

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: The root of Polygala tenuifolia, a traditional Chinese medicine, has been used to improve memory and intelligence, while the underlying mechanisms remain largely unknown. In this study, we investigated the protective effects of senegenin, an component of Polygala tenuifolia root extracts, on cognitive dysfunction induced by hepatic ischemia-reperfusion. Methodology/Principal Findings: Initially, we constructed a rat model of hepatic ischemia-reperfusion (HIR) and found that the memory retention ability of rats in the step-down and Y maze test was impaired after HIR, paralleled by a decrease of N-methyl-D-aspartate (NMDA) receptor NR2B subunit mRNA and protein expressions in hippocampus. Furthermore, we found that administration of senegenin by gavage attenuated HIR-induced cognitive impairment in a dose and time dependent manner, and its mechanisms might partly due to the increasing expression of NR2B in rat hippocampus. Conclusions/Significance: Cognitive dysfunction induced by HIR is associated with reduction of NR2B expression. Senegenin plays a neuroprotective role in HIR via increasing NR2B expression in rat hippocampus. These findings suggest that senegenin might be a potential agent for prevention and treatment of postoperative cognitive dysfunction (POCD) or other neurodegenerative diseases.

引用

页数：7