SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions

被引：137

作者：

Euskirchen, Ghia ^{[1
]}

Auerbach, Raymond K. ^{[2
]}

Snyder, Michael ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 37期

关键词：

MALIGNANT RHABDOID TUMORS; DNA-BINDING PROPERTIES; CANCER CELL-LINES; FREQUENT MUTATIONS; ACTIVE CHROMATIN; GENE-EXPRESSION; COMPLEX; PROTEIN; ACTIVATION; INTEGRASE;

D O I：

10.1074/jbc.R111.309302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes.

引用

页码：30897 / 30905

页数：9

共 94 条

[91] Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance [J].

Yung, E ;

Sorin, M ;

Wang, EJ ;

Perumal, S ;

Ott, D ;

Kalpana, GV .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2222-2231

[92] Reprogramming of the SWI/SNF complex for co-activation or co-repression in prohibitin-mediated estrogen receptor regulation [J].

Zhang, B. ;

Chambers, K. J. ;

Faller, D. V. ;

Wang, S. .

ONCOGENE, 2007, 26 (50) :7153-7157

[93] DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC [J].

Zhang, Yongli ;

Smith, Corey L. ;

Saha, Anjanabha ;

Grill, Stephan W. ;

Mihardja, Shirley ;

Smith, Steven B. ;

Cairns, Bradley R. ;

Peterson, Craig L. ;

Bustamantel, Carlos .

MOLECULAR CELL, 2006, 24 (04) :559-568

[94] Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome [J].

Zofall, M ;

Persinger, J ;

Kassabov, SR ;

Bartholomew, B .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (04) :339-346

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