SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions

被引：137

作者：

Euskirchen, Ghia ^{[1
]}

Auerbach, Raymond K. ^{[2
]}

Snyder, Michael ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 37期

关键词：

MALIGNANT RHABDOID TUMORS; DNA-BINDING PROPERTIES; CANCER CELL-LINES; FREQUENT MUTATIONS; ACTIVE CHROMATIN; GENE-EXPRESSION; COMPLEX; PROTEIN; ACTIVATION; INTEGRASE;

D O I：

10.1074/jbc.R111.309302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes.

引用

页码：30897 / 30905

页数：9

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